By the Numbers: Thanksgiving travel nearing pre-pandemic levels.

Some 53 million Americans are expected to travel on the roads and in the skies this Thanksgiving holiday, as travel volume reaches near pre-pandemic levels.

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Economic impact of new COVID-19 variant omicron

Economic impact of new COVID-19 variant omicron

Yahoo finance reporter Alexis Christoforous discusses the risks of the new omicron variant and the economic impact in terms of inflation, unemployment, supply chain issues and more.

Omicron variant drives fears of potential new COVID-19 wave.

Omicron variant drives fears of potential new COVID-19 wave.

ABC News contributor Dr. John Brownstein speaks on the effectiveness of the vaccine and COVID-related mandates after the omicron variant became present in more than a dozen countries.

South Africa’s concern with omicron COVID-19 variant.

South Africa’s concern with omicron COVID-19 variant.

ABC News producer Liezl Thom joins from Pretoria, South Africa, to share insight on the new omicron COVID-19 variant and how the country is responding.

ABC News Prime: Omicron variant; Ghislaine Maxwell trial begins; Conversation with Mel Brooks.

ABC News Prime: Omicron variant; Ghislaine Maxwell trial begins; Conversation with Mel Brooks.

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First lady Jill Biden unveils White House holiday decorations.

First lady Jill Biden unveils White House holiday decorations.

The first lady’s theme for the 2021 holiday season is "Gifts from the Heart."