Boris Johnson again begged the nation to pull together and follow the rules in order to avoid another national lockdown.
He said only a "collective" effort and willingness to make "sacrifices" for the rest of the country would produce progress in bringing cases down.
"We will not hesitate to take further measures which would be more costly," he warned.
Mr Johnson told Brits tonight: "No matter how impatient we may become, how fed up we may become, we must show collective forbearance, common sense and willingness to make sacrifices for others."
In the face of a Tory rebellion over his coronavirus strategy, Boris said we must stick together "with confidence".
He warned of a "huge" loss of life if Brits didn't follow the rules and gave up.
And again he refused to give in to critics who say the nation should "give up" and "let the virus take its course".
He hit back after days of Tories attacking his handling of the pandemic: "I profoundly disagree and I don't think its what British people want.
"They don't want to throw in the sponge, they want to fight and defeat this virus."
Boris Johnson speech – PM tells Brits we can’t throw in the sponge now despite us being ‘impatient or fed up’
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