Highly Effective Antibodies Identified, May Lead To Passive COVID-19 Vaccine.

NDTV News

NDTV.com provides latest news from India and the world. Get today’s news headlines from Business, Technology, Bollywood, Cricket, videos, photos, live news coverage and exclusive breaking news from India.

https://www.ndtv.com/

Highly Effective Antibodies Identified, May Lead To Passive COVID-19 Vaccine

Effect of a passive vaccination is almost immediate, the researchers said.(Representational)

Berlin:

Scientists have identified highly effective antibodies against the novel coronavirus, which they say can lead to the development of a passive vaccination for COVID-19.

Unlike in active vaccination, passive vaccination involves the administration of ready-made antibodies, which are degraded after some time.

However, the effect of a passive vaccination is almost immediate, whereas with an active vaccination it has to build up first, the researchers said.

The research, published in the journal Cell, also shows that some SARS-CoV-2 antibodies bind to tissue samples from various organs, which could potentially trigger undesired side effects.

The scientists at the German Center for Neurodegenerative Diseases(DZNE)and Charite - Universitatsmedizin Berlin isolated almost 600 different antibodies from the blood of individuals who had overcome COVID-19, the disease triggered by SARS-CoV-2.

By means of laboratory tests, they were able to narrow this number down to a few antibodies that were particularly effective at binding to the virus.

The researchers then produced these antibodies artificially using cell cultures.

The so-called neutralising antibodies bind to the virus, as crystallographic analysis reveals, and thus prevent the pathogen from entering cells and reproducing, they said.

In addition, virus recognition by antibodies helps immune cells to eliminate the pathogen. Studies in hamsters -- which, like humans, are susceptible to infection by SARS-CoV-2 -- confirmed the high efficacy of the selected antibodies.

"If the antibodies were given after an infection, the hamsters developed mild disease symptoms at most. If the antibodies were applied preventively -- before infection -- the animals did not get sick," said Jakob Kreye, coordinator of the research project.

The researchers noted that treating infectious diseases with antibodies has a long history.

Newsbeep


For COVID-19, this approach is also being investigated through the administration of plasma derived from the blood of recovered patients. With the plasma, antibodies of donors are transferred, they said.

"Ideally, the most effective antibody is produced in a controlled manner on an industrial scale and in constant quality. This is the goal we are pursuing," said Momsen Reincke, first author of the research.

"Three of our antibodies are particularly promising for clinical development," explained Harald Pruss, a research group leader at the DZNE and also a senior physician at Charite - Universitatsmedizin Berlin.

"Using these antibodies, we have started to develop a passive vaccination against SARS-CoV-2," Pruss said.

In addition to the treatment of patients, preventive protection of healthy individuals who have had contact with infected persons is also a potential application, the researchers said.

How long the protection lasts will have to be investigated in clinical studies, they said.

"This is because, unlike in active vaccination, passive vaccination involves the administration of ready-made antibodies, which are degraded after some time," Pruss said. In general, the protection provided by a passive vaccination is less persistent than that provided by an active vaccination, the researchers said.

However, the effect of a passive vaccination is almost immediate, whereas with an active vaccination it has to build up first, they said.

"It would be best if both options were available so that a flexible response could be made depending on the situation," Pruss added.

(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)

Related news

Biden facing mounting pressure to expand diversity in U.

Of the nine major picks Biden has made so far, only two — Secretary of State choice Antony Blinken and chief of staff Ron Klain — are white men.

Number of COVID-19 cases confirmed worldwide exceeds 66 mln.

The overall death toll is 1,521,598 people, while 42,484,682 coronavirus patients have already recovered.

Trump administration must accept new DACA applications, judge says.

The Trump administration had announced the end of the program in 2017, leading to the legal challenges that wound up in front of the Supreme Court.

Cargo ship attacked off Yemen in the Gulf of Aden: authorities.

A cargo ship travelling past Yemen in the Gulf of Aden came under attack in unclear circumstances, maritime authorities said Saturday.

European Union, U.K. leaders to hold crunch talks to break Brexit impasse

EU chief negotiator Michel Barnier and his British counterpart, David Frost, agreed Friday to ``pause'' negotiations while they brief political leaders.

Moscow Starts Mass COVID-19 Vaccination With Its Sputnik V Shot.

Moscow began distributing the Sputnik V COVID-19 shot via 70 clinics on Saturday, marking Russia's first mass vaccination against the disease, the city's coronavirus task force said.

Trump Plan Junked, Obama-Era Shield On Immigrants Back;Indians Benefit.

Reversing the decision of the outgoing Trump administration, a federal court has ordered full reinstatement of an Obama-era programme that protects undocumented immigrants brought to the US as minors...

Kuwait Holds Parliamentary Election Under Shadow Of Virus.

Kuwaitis went to the polls on Saturday in a parliamentary election overshadowed by Covid-19, with facilities laid on for citizens infected with the disease to vote in special polling stations.

18 Miners Killed In Coal Mine Accident In China

Eighteen people have died after being trapped in a mine in China's southwestern city of Chongqing, the official Xinhua news agency said on Saturday, the region's second such accident in just over two...

«Soft Power Propaganda Tools» : US Ends Exchange Programs With China.

The US State Department said on Friday it has ended five cultural exchange programs with China, calling them "soft power propaganda tools."