COVID-19 Antibody Therapy May Lower Hospitalisations, Finds Study.

NDTV News provides latest news from India and the world. Get today’s news headlines from Business, Technology, Bollywood, Cricket, videos, photos, live news coverage and exclusive breaking news from India.

COVID-19 Antibody Therapy May Lower Hospitalisations, Finds Study

Those who got COVID-19 antibody therapy had fewer symptoms, less likely to require hospitalisation

Los Angeles:

COVID-19 patients who were administered a novel antibody had fewer symptoms and were less likely to require hospitalisation or emergency medical care than those who did not receive the therapy, according to a new study.

The ongoing Phase II clinical trial, whose interim results were published in The New England Journal of Medicine, tested three different doses of LY-CoV555, a monoclonal antibody derived from the blood of a recovered COVID-19 patient.

The analysis indicated a reduced viral load in outpatients with mild to moderate cases of COVID-19 at the 2,800-milligram dosage level, along with reduced rates of hospitalisation and emergency medical care among patients at all dosage levels.

"For me, the most significant finding was the reduction in hospitalisations," said the study's co-first author, Peter Chen from the Cedars-Sinai Medical Center in the US.

"Monoclonal antibodies like this have the potential to reduce the severity of COVID-19 for many patients, allowing more people to recover at home," Mr Chen said.

According to the researchers, monoclonal antibodies work by attaching themselves to a virus and preventing it from replicating.

They said LY-CoV555 binds to a particular protein on the novel coronavirus, called the spike protein, which the virus needs to enter human cells and replicate.

By preventing the virus from replicating, the scientists said the antibody slows down the replication process, allowing the patient's own immune system time to kick into gear.

"What we're doing is preventing the virus from causing too much damage early on in the process," Mr Chen said.

"We're buying the patients time, so that their bodies can start developing their own immunity to fight the virus," he added.

In the study, the patients were given intravenous doses of either 700, 2,800 or 7,000 milligrams of the antibody, or a placebo.

"In this interim analysis of a phase 2 trial, one of three doses of neutralising antibody LY-CoV555 appeared to accelerate the natural decline in viral load over time, whereas the other doses had not by day 11," the scientists wrote in the study.

The researchers used a nasopharyngeal swab to test patients' viral load before administering the antibody and again at several points after administering the drug.

They also gave the patients a questionnaire about their subsequent symptoms and treatment.


According to the study, nearly 300 patients received the treatment(100 patients per dosage level), and approximately 150 patients received the placebo.

Of the three dosage levels, the scientists said the 2,800-milligram dosage was shown to be effective in reducing viral load.

By day 11, they said the viral load was substantially diminished for most patients, including those in the placebo arm.

However the researchers said further studies will be needed to validate these results.

"The publication of these data in a peer-reviewed journal adds to the growing body of evidence for the potential utility for neutralising antibodies as therapeutics for people recently diagnosed with mild to moderate COVID-19, particularly high-risk patients," said Ajay Nirula, another co-author of the study.

"These data show LY-CoV555 may be effective in treating COVID-19 by reducing viral load, symptoms and the risk of hospitalisation in outpatients," Mr Nirula said.

At day 29, the study noted that hospitalisation rates were only 1.6 per cent in the antibody-treated group, compared with 6.3 per cent in the group that received the placebo.

The researchers said the reduction in hospitalisations was seen across all demographic groups, including those in high-risk categories - adults older than 65 and those with a high body mass index(greater than 35).

For high-risk patients, they said the hospitalisation rates were 4.2 per cent in patients treated with the antibody, compared with 14.6 per cent in placebo-treated patients.

The safety profile of patients treated with LY-CoV555 was similar to that of placebo-treated patients, the study noted.

"We know that COVID-19 is especially hard on the elderly, the obese and people with certain pre-existing health conditions," Mr Chen said.

"Antibody treatments like this may have the most benefits for people in these higher-risk categories," he added.

(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)

Related news

Iranian Commander Killed In Airstrike At Iraq-Syria Border.

An air strike killed a commander of Iran's Revolutionary Guards at the Iraq-Syria border sometime between Saturday and Sunday, Iraqi security and local militia officials said on Monday.

Saudi Arabia To Let Israeli Planes Cross Its Airspace, Says Trump Offcial.

Saudi Arabia agreed on Monday to let Israeli airliners cross its airspace en route to the United Arab Emirates after talks between Saudi officials and White House senior adviser Jared Kushner, a...

Deforestation In Brazil's Amazon Surges To 12-Year High.

Deforestation in the Brazilian Amazon surged again over the past year, hitting a 12-year high, according to official figures released Monday that drew a chorus of condemnation of President Jair...

Nuke Scientist Killed In «New, Complex» Operation: Top Iranian Official.

A top Iranian official Monday said nuclear scientist Mohsen Fakhrizadeh was killed in a new type of "complex operation", blaming arch-foe Israel and an exiled opposition group.

U.S. Election: Top Georgia official announces investigations, defends voting integrity

Secretary of State Brad Raffensperger has repeatedly said there has been no evidence of systemic election irregularities or fraud, but said that his office is investigating any credible claims of illegal voting and violations of state election law.

Lahore Tops List Of World's Most Polluted Cities, Delhi Ranks Second.

Pakistan's cultural capital Lahore has once again topped the list of world's most polluted cities.

Iran Has Nothing To Gain From Halting Inspections: Nuclear Watchdog.

Iran has nothing to gain from ending inspections of nuclear facilities, the head of the UN's nuclear watchdog told AFP on Monday.

Biden, Kamala Harris Send Greetings On Guru Nanak's Birth Anniversary.

Sending their warmest wishes on the 551st birth anniversary of Guru Nanak Dev, President-elect Joe Biden and his deputy Kamala Harris on Monday said the founder of Sikhism's timeless and universal...

Man lost at sea found alive, clinging to capsized boat off Florida coast.

Richard Bee, 62, was found alive on the remains of his boat on Sunday, two days after he ventured out from Port Canaveral in Florida.

Moderna’s technology for coronavirus vaccine was designed in 2 days — here’s how.

In early January, when the coronavirus was still a mysterious virus in China, Moderna started chasing a potential vaccine for the disease.

1 803