AstraZeneca's Antibody Cocktail Fails to Prevent Covid: Study.

AstraZeneca's Antibody Cocktail Fails to Prevent Covid: Study

US has ordered up to 700,000 doses of the AstraZeneca antibody cocktail.

AstraZeneca Plc's antibody cocktail was only 33% effective at preventing COVID-19 symptoms in people who had been exposed to the virus, failing a study that was key to the drugmaker's pandemic push.

The trial of 1,121 adult volunteers looked at whether the long-acting antibody combination could protect people who had recently been in contact with the SARS-CoV-2 virus in places like care homes. The company said it's running other studies of the medicine that could help clarify the findings.

The outcome is a blow to Astra for a drug that was hoped to be a bright spot in the company's pandemic efforts following the mixed success of its vaccine with the University of Oxford. Other drugmakers such as GlaxoSmithKline Plc have had some success in getting similar therapies through clinical tests and approved for people who are at risk of severe disease or can't get vaccinated.

"There is still a significant need for prevention and treatment options for certain populations, including those unable to be vaccinated or those who may have an inadequate response to vaccination," said Myron Levin, the study's lead researcher and a professor of medicine at the University of Colorado.

The Astra medicine attracted interest even before it could prove its efficacy. The US has ordered up to 700,000 doses of the medicine for delivery in 2021, while the UK was already reconsidering an earlier order for one million.

Astra shares were little changed in London trading, rising 0.6%.

Some Promise

The study, conducted in the US and UK, showed 23 volunteers who got the cocktail developed symptomatic COVID-19 following exposure to the disease, compared with 17 cases in the placebo group, according to a statement Tuesday. Twice as many participants got the antibody, but the difference between the two groups wasn't considered statistically significant.

Further analysis showed the drug had some impact in preventing disease for those who weren't infected at the time of dosing.

Volunteers who became infected up to a week after taking the drug were 51% less likely to develop symptoms, the company said. That climbed to 92% if the patient didn't record infection until more than a week after the injection. All participants had a negative antibody test when dosed to exclude prior infection.

The trial, named Storm Chaser, is one of six advanced-stage studies Astra is running to test the medicine. Another one called Provent, looking at whether the cocktail can prevent infection in people at high risk of catching Covid or with compromised immune systems, is also expected to report results soon.

Antibody drugs are viewed as a way to protect people such as cancer patients whose immune systems may not respond as well to vaccines. They may also provide much-needed treatments as countries encounter new variants and waves of infections amid varying speeds of vaccine rollouts. A number of companies are testing antibody drugs as measures of both prevention and treatment.

Several antibody treatments are already on sale. Glaxo and Vir Biotechnology Inc. received US emergency-use authorization for their product last month after it showed it could kept at-risk patients from worsening. Eli Lilly & Co.'s authorization for an antibody treatment was revoked in April amid questions over its effectiveness, but the company then had the product cleared for use in combination with another antibody.

(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)

NDTV News

NDTV.com provides latest news from India and the world. Get today’s news headlines from Business, Technology, Bollywood, Cricket, videos, photos, live news coverage and exclusive breaking news from India.

https://www.ndtv.com/

Related news
Cuban-Americans rally outside of White House: 'We want our freedom'.

Cuban-Americans rally outside of White House: 'We want our freedom'.

Luis Luchuga Jr., who fled Cuba at 8 years old, says the protesters are sending a message to the Biden administration that the Cuban people need help. Subscribe to Fox News! Watch more Fox News Video: Watch Fox News Channel Live: FOX News Channel ...

Epidemics Don't Have to Happen, Expert Says

Epidemics Don't Have to Happen, Expert Says

New research shows many through proper policies and community outreach epidemics can be prevented or at least largely contained

With Taliban Resurgence, Afghan Women Worry About Future.

With Taliban Resurgence, Afghan Women Worry About Future.

The group’s past refusal to accept women's freedoms and rights has many worried that any progress made in the past two decades will be erased

CDC considers revising mask guidance as delta variant spreads.

CDC considers revising mask guidance as delta variant spreads.

Dr. Anthony Fauci confirmed that the CDC is considering revising the mask guidance for fully vaccinated people as COVID-19 cases skyrocket 314% since mid-June.

Live: Biden Delivers Remarks On Anniversary Of Americans With Disabilities Act - NBC News.

Live: Biden Delivers Remarks On Anniversary Of Americans With Disabilities Act - NBC News.

President Joe Biden delivers remarks to celebrate the 31st anniversary of the Americans with Disabilities Act, which the president co-sponsored as a senator in 1990. » Subscribe to NBC News: » Watch more NBC video: NBC News Digital is a collection...

Live: White House Holds Press Briefing - NBC News

Live: White House Holds Press Briefing - NBC News

Watch as White House Press Secretary Jen Psaki holds a press briefing. » Subscribe to NBC News: » Watch more NBC video: NBC News Digital is a collection of innovative and powerful news brands that deliver compelling, diverse and engaging news stor...